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In terms of the interplay between ERS and the immune microenvironment, research has revealed that ERS-induced ICD exhibits dual regulatory properties

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The ApoA-I Milano mutation is associated with low levels of HDL-C and reduced risk of CVD (747)

However, inducing angiogenesis should be undertaken with caution, as inducing the formation of new blood vessels in areas where cancer cells are still present can facilitate tumor growth and could allow the cells to enter the systemic blood flow, with the possibility of inducing metastasis (Muz et al., 2015)